About REVTORPYK
Explore who REVTORPYK is for
Your oncologist may prescribe REVTORPYK in combination with the medicine fulvestrant, with or without palbociclib, if your breast cancer…
- is HR+ and HER2-
- is advanced
- has progressed after at least 1 line of hormone (endocrine) therapy for metastatic disease
- does not have a detectable PIK3CA mutation (ask your oncologist if you do not know if your cancer has this mutation)
What if I’ve taken a CDK4/6 inhibitor before?
REVTORPYK can still be a treatment option for you. In fact, it was specifically studied in patients who had previously taken a CDK4/6 inhibitor and hormone therapy in the advanced setting.
REVTORPYK is a targeted medicine given as an IV infusion that stops or slows cancer cells from growing
REVTORPYK is not chemotherapy
Understanding your type of breast cancer
What is HR+/HER2- breast cancer?
HR+
When your breast cancer cells have receptors that attach to the hormones estrogen or progesterone, they are called hormone receptor positive (HR+). These hormones can attach to the receptors and help cancer cells grow.
HER2-
HER2 is a protein that helps control breast cancer cell growth. When your breast cancer cells have low to no detectable levels of HER2, the cancer is called HER2 negative (HER2-).
What does it mean to have ABC?
If you have ABC, it usually means the cancer cells have spread from the breast to other parts of the body, which can include distant or nearby tissues, or lymph nodes. ABC can also be referred to as “locally advanced” or “metastatic breast cancer.”
What is PIK3CA?
PIK3CA is a gene that, when altered (mutated), can be involved in HR+/HER2- breast cancer progression. Your doctor may give you a test to find out if your PIK3CA gene is altered, which may impact the treatment you receive.
REVTORPYK is the first and only treatment of its kind approved for previously treated HR+/HER2- ABC
Based on lab studies, REVTORPYK inhibits key parts of an important pathway that HR+/HER2- breast cancer uses to grow
Even with hormone therapy, some breast cancer cells find a way to keep growing by using “the PAM pathway.”
The PAM pathway has 3 main parts that tell cancer cells to grow. These 3 parts are called:
PI3K, AKT, and mTOR.
REVTORPYK is the only treatment that inhibits the 3 main parts of the PAM pathway.
The PAM pathway is also known as the PI3K/AKT/mTOR pathway.
What is a pathway?
A pathway, or cell signaling pathway, is a system of messages inside a cell that controls how it grows and behaves. In cancer, some of these signals can become too active and cause cells to do things they shouldn't.
